Unfolding the chaperone story
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Unfolding the chaperone story
Protein folding in the cell was originally assumed to be a spontaneous process, based on Anfinsen's discovery that purified proteins can fold on their own after removal from denaturant. Consequently cell biologists showed little interest in the protein folding process. This changed only in the mid and late 1980s, when the chaperone story began to unfold. As a result, we now know that in vivo, p...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2017
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e17-07-0480